Video: Conjugate Addition of Enolates: Michael Addition
Video: Conjugate Addition of Enolates: Michael Addition
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Organic Name Reactions on Instagram: "The Michael addition enables the conjugate (1,4-) addition of carbon nucleophiles to α,β-unsaturated compounds, forming new C–C bonds via attack at the β-carbon. Typical C-nucleophiles include enolates, stabilized carbanions (e.g., malonates, β-dicarbonyls, etc.), and organocuprates. First described by Arthur Michael in the late 19th century, the reaction proceeds through enolate addition to the activated alkene followed by protonation, favoring thermodynami
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