ALSP is caused by mutations in the CSF1R gene. This gene provides instructions for making a protein called colony stimulating factor 1 receptor (CSF-1 receptor), which is found in the outer …

The presenting symptoms and disease progression of ALSP can vary greatly from person to person, making diagnosis difficult. As the disease advances, there is a severe decline in …

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare, progressive brain disease. ALSP damages white matter (tissue in the brain), which can lead to …

While there are genetic similarities, CSF1R-ALSP typically appears in adulthood whereas BANDDOS manifests earlier and more severely, often from birth or infancy.

Understand ALSP, a rare inherited disorder of the brain’s white matter. This article explains how a CSF1R gene mutation informs diagnosis and patient care.

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare, rapidly progressive neurodegenerative disease affecting the white matter and typically …

ALSP can only be confirmed with genetic testing, which makes it particularly important to ensure the correct diagnosis is made. The progression of ALSP to the final stages of the disease can …

Feb 19, 2025 · People with ALSP present with a rare and progressive neurological disease in which the brain tissue known as white matter wastes away (leukodystrophy) forming lesions in …

Mar 11, 2024 · Introduction: Because adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare, rapidly progressive, debilitating, and ultimately fatal …

Patient advocacy group for those diagnosed with ALSP, adult-onset leukoencephalopathy with axonal spheroids and pigmented glia, HDLS and CSF1R related disorders.