The New Orleans Saints were not able to pull off the upset late against the Buffalo Bills, losing 31-19. The Saints now fall to 0-4 for the first time since 2012.

The New Orleans Saints have been one of the worst teams in football this year. They're 0-4 on the season with losses to the Arizona Cardinals, San Francisco 49e

The Bills took care of business Sunday afternoon and defeated the New Orleans Saints 31-19 at Highmark Stadium, and elsewhere, the Los Angeles Chargers and Indianapolis Colts both lost, leaving the Bills alone atop the conference in the race for the No. 1 seed, a race that is never too early to start thinking about in the NFL.

Watch New Orleans Saints head coach Kellen Moore's postgame interview after the Saints' game at the Buffalo Bills in Week 4 of the 2025 NFL season.

The New Orleans Saints got some pieces back heading into their Week 4 matchup against the Buffalo Bills but also got bitten by the injury bug on Sunday afternoo

I want to just keep the same mindset of, ‘I got to go earn my role.’ Nothing’s given right now,” Shough tells PEOPLE

Kendre Miller's 18-yard touchdown run wasn't just his third career TD. It was the first opening-drive touchdown the Saints had since last November: