With the potential loss of Brandon Aiyuk, the 49ers could get Christian McCaffrey back from injury as soon as they return ...

The San Francisco 49ers lost a few of their key pieces in Week 7, including Deebo Samuel, who only played four snaps.

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy had a long locker room discussion after Sunday's ...

Break out your thesaurus because we'll need plenty of words to describe the sloppy San Francisco 49ers. Yes, this is still ...

When the Dallas Cowboys travel to face the San Francisco 49ers in Week 8, the 49ers may be without another one of their key offensive weapons.

Quarterbacks Jayden Daniels and Deshaun Watson and wide receiver Brandon Aiyuk were among key players injured in Week 7 of ...

The San Francisco 49ers sustained an ugly defeat against Kansas City Chiefs, maybe providing some upset hope for their old rivals the Dallas Cowboys.

The 49ers are 3-4 and have been dealing with injuries all season. They could strike a trade to help save the season.

Injuries are an unfortunate inevitability in the NFL, and Week 7 has been no exception. The injury bug has taken its fair ...

With the injury to Brandon Aiyuk, fantasy football managers are left with a void on their roster. Let’s check out the extent ...

The 49ers are off to a slow start to the season after reaching the Super Bowl last year. Injuries have not been kind to the ...

Kansas City Chiefs tight end Travis Kelce, left, cannot catch a pass while being defended by San Francisco 49ers cornerback ...