Get the best Jaguars vs. 49ers predictions ahead of Sunday's clash at Levi's Stadium. Free NFL picks for September 28.

Sunday is a grand opportunity for the Jacksonville Jaguars. They will travel to the West Coast to take on the 3-0 San Francisco 49ers, a team that, when healthy

NFL teams have coach-to-player communication via helmet radio, but coaches and players still use hand signals before the snap to make changes to their pass rush and coverage calls. The way Saleh sees it, the Jaguars have been able to translate those signals and thus get into a better play at the line of scrimmage.

The Jacksonville Jaguars will face San Francisco 49ers quarterback Brock Purdy on Sunday after he missed two games with a toe injury.

Jacksonville had the second pick in the draft; on paper, that’s an easy 49er win. On the field, this won’t be easy.

The Jacksonville Jaguars defeated the Houston Texans thanks to a smart decision from quarterback Trevor Lawrence.

Despite being hit hard by injuries the San Francisco 49ers remain undefeated heading into Week 4. Next up on the schedule they host the Jacksonville Jaguars and thankfully QB Brock Purdy is reentering the lineup.

Many aren't taking the Jaguars seriously yet, despite their 2-1 start to the 2025 NFL season. Don't count 49ers Head Coach Kyle Shanahan among them.