Researchers at Karolinska Institutet have identified small molecules capable of influencing a hard-to-target receptor family ...

Researchers have unveiled the intricate molecular mechanisms governing TCF/LEF-mediated transcription in the canonical Wnt pathway, identifying these proteins as promising therapeutic targets for ...

The four helices conserved across the Lipocone superfamily constitute a cone-like structure, with the helices tending to coalesce on one end and open out into a pocket on the other, lined by the ...

Add a comment + Open annotations. The current annotation count on this page is being calculated. Researchers have described a large set of previously unrecognised enzymatic domains – named the ...

Chronic subcutaneous spexin (50 µg kg⁻¹ day⁻¹ for 4 weeks) not only amplifies ischaemia–reperfusion-induced AKI in male BALB/c mice but also provokes ...

A study links graying hair to stem cells getting stuck, unable to color new hair growth. Stem cells travel back and forth within compartments, but when they get stuck in one compartment, they cannot ...

Select members of the Wnt family of secreted glycoproteins have been implicated in inducing the myogenic determinant genes Pax3, MyoD and Myf5 during mammalian embryogenesis(1,2), but the mechanism of ...

Objective: This study examined the effects of Echinococcus multilocularis infection on the activation of the Wnt signaling pathway in hepatocytes, its association with epithelial-mesenchymal ...

1 Chengdu Integrated TCM and Western Medicine Hospital, Department of Traditional Chinese Medicine Pharmacy, Chengdu, China 2 Henan University of Traditional Chinese Medicine, Department of ...