Basic research, often termed fundamental, frontier, blue-sky, curiosity-driven—or even useless—is the pursuit of knowledge ...

USP17LA loss enhances T-cell function and anti-tumor activity in murine tumor models. Usp17la-deficient T cells exhibit ...

My PhD supervisor, Bob, kindly shared his CV with me and recommended that I peruse other scientists’ research webpages for theirs. Sure enough, many researchers in my field had a link next to their ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The tumor microenvironment (TME) presents ...

A differential genetic interaction screen performed in different stress conditions shows that genetic interactions are often context specific. Conditional genetic interactions recapitulate known ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Esophageal squamous cell carcinoma (ESCC) is ...

Elevated expression of the X‐linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In activated B cells, activation‐induced ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Specific and non-invasive diagnostic tools are ...

Senescent cells secrete bioreactive molecules that promote disease, fibrosis, and aging, yet the molecular mechanisms driving the production of these secreted factors remain incompletely understood.

LINE1 (L1) retrotransposons have gained notoriety for their involvement in a slew of pathologies. While improper de-repression of L1 transcription may drive disease, mammalian cells have coopted L1 ...

In this report, we describe a unique human UBL‐type modifier named u biquitin‐ f old m odifier 1 (Ufm1) that is synthesized in a precursor form consisting of 85 amino‐acid residues. We also identified ...