My PhD supervisor, Bob, kindly shared his CV with me and recommended that I peruse other scientists’ research webpages for theirs. Sure enough, many researchers in my field had a link next to their ...

The protein homeostasis (proteostasis) network (Balch et al, 2008), consisting of a collection of molecular chaperones, ...

The enteric nervous system (ENS), the largest division of autonomic nervous system, is a tantalizing frontier in neuroscience. With the advent of single-cell transcriptomics, the ENS has been ...

Inherited metabolic diseases are rare monogenic conditions that disrupt biochemical pathways, affecting energy production and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neuronal presynaptic terminals contain ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Substrate specificity determines protease ...

Senescent cells secrete bioreactive molecules that promote disease, fibrosis, and aging, yet the molecular mechanisms driving the production of these secreted factors remain incompletely understood.

In this report, we describe a unique human UBL‐type modifier named u biquitin‐ f old m odifier 1 (Ufm1) that is synthesized in a precursor form consisting of 85 amino‐acid residues. We also identified ...

Autophagy is a major pathway for delivery of proteins and organelles to lysosomes/the vacuole, where they are degraded and recycled. Autophagy plays an essential role in differentiation and ...

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Rab7 regulates vesicle traffic from early to late endosomes, and from late endosomes to lysosomes. The crystal structure of Rab7‐GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 ...