Europe PMC

Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.

Authors Ramezani-Rad P 1, 2 Cottrell CA 2 Marina-Zárate E 1, 2 Liguori A 2 Landais E 2 Myers A 1, 2 Lee JH 2 Baboo S 2 Flynn C 2 McKenney K 2 Salcedo E 2 Zhou X 2 Kalyuzhniy O 2 Georgeson E 2 Phelps N ...
Europe PMC

Dasatinib Induced Pulmonary Hypertension and Third Space Effusion: A Case Series and Literature Review

Dasatinib Induced Pulmonary Hypertension and Third Space Effusion: A Case Series and Literature ReviewPura Krishnamurthy K 1 , Mahadevappa M 1 , Srinivasan B 2 , Jayaprakash Narayan H 2 ...
Europe PMC

The C-terminal Kinase Domain-Binding and Suppression Motif Prevents Constitutive Activation of FGFR2.

Abstract Genetic alterations in receptor tyrosine kinase (RTK) genes can generate potent oncogenic drivers. Truncation of the fibroblast growth factor receptor 2 (FGFR2) gene by its last exon 18 (E18) ...
Europe PMC

Interpretation of Blood Clotting Studies and Values (PT, PTT, aPTT, INR, Anti-Factor Xa, D-Dimer)

Interpretation of Blood Clotting Studies and Values (PT, PTT, aPTT, INR, Anti-Factor Xa, D-Dimer) ...
Europe PMC

Glycolytic enzymes in non-glycolytic web: functional analysis of the key players.

To survive in the tumour microenvironment, cancer cells undergo rapid metabolic reprograming and adaptability. One of the key characteristics of cancer is increased glycolytic selectivity and ...
Europe PMC

De novo annotation of the wheat pan-genome reveals complexity and diversity of the hexaploid wheat pan-transcriptome

Wheat is the most widely cultivated crop in the world with over 215 million hectares grown annually. However, to meet the demands of a growing global population, breeders face the challenge of ...
Europe PMC

Combined biochar and water-retaining agent application increased soil water retention capacity and maize seedling drought resistance in Fluvisols.

Global climate change has accelerated the occurrence of agricultural drought events, which threaten food security. Therefore, improvements in the soil water retention capacity (WRC) and crop drought ...
Europe PMC

Challenges and solutions in laparoscopy for super obese gynecological patients: an elderly endometrial cancer patient.

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Europe PMC

A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers.

Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1) blockade in cancer patients, but the mechanisms underlying their immunosuppressive effects remain unknown. By ...
Europe PMC

The Involvement of Lactic Acid Bacteria and Their Exopolysaccharides in the Biosorption and Detoxication of Heavy Metals in the Gut.

Heavy metal pollution has become one of the most important global environmental issues. The human health risk posed by heavy metals encountered through the food chain and occupational and ...
Europe PMC

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

Antisense oligonucleotides (ASO) are promising therapies for neurological disorders, though they are unable to cross the blood-brain barrier (BBB) and must be delivered directly to the central nervous ...
Europe PMC

COVID-19 Vaccines: The Impact on Pregnancy Outcomes and Menstrual Function

Objectives: Assess rates of adverse events (AE) after COVID-19 vaccines experienced by women of reproductive age, focusing on pregnancy and menstruation, using data collected by the US Centers for ...