eLife4h
Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model
Pancreatic cancer-associated muscle atrophy is characterized by strong mitochondrial metabolic defects that are not limited to carbohydrate, protein, and redox metabolism, but also concern lipid and ...
eLife3h
Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression
This valuable study addresses potential roles of the master regulator of X chromosome inactivation, the Xist long non-coding RNA, in autosomal gene regulation. Using data from mouse cells, the authors ...
eLife3d
Discovering Root Causal Genes with High Throughput Perturbations
We now introduce an algorithm called Root Causal Strength using Perturbations (RCSP) that discovers the surrogate ancestors of each variable using Perturb-seq and then computes the RCS of each ...
eLife2d
Range geographies, not functional traits, explain convergent range and phenology shifts under climate change
This article presents valuable findings on the impact of climate change on odonates, integrating phenological and range shifts to broaden our understanding of biodiversity change. The study leverages ...
eLife2d
Vole Parenting: A fine line between attack and care
Oxytocin neuron projections from two brain regions involved in parental care regulate both parental care and infanticidal behaviors in virgin mandarin voles.
eLife2d
Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism
Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences; Peking University International Cancer Institute; and State Key Laboratory ...
eLife4d
A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide
The findings are significant for the liver research community and others interested in the gut-liver axis. (A) AOAH cleaves the two piggyback fatty acyl chains from the lipid A moiety, inactivating ...
eLife3d
Amidase and Lysozyme Dual Functions in TseP Reveal a New Family of Chimeric Effectors in the Type VI Secretion System
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, ...
eLife3d
Arthropods dominate plant litter decomposition in drylands
An analysis of leaf litter breakdown in climatically diverse habitats shows that decomposition by larger invertebrates dominates in hot, dry regions and warmer seasons.
eLife3d
Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer
The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies. Non-small cell lung cancer (NSCLC) is the most common subtype of lung ...
eLife3d
Reconstructing the evolutionary history of freshwater fishes (Nemacheilidae) across Eurasia since early Eocene
Series of paleomaps visualising the geographical and chronological aspects of the main events during the evolutionary history of the freshwater fish family Nemacheilidae across Eurasia. A red star ...
eLife3d
HIV integrase compacts viral DNA into biphasic condensates
Soft Condensed Matter and Biophysics, Department of Physics and Debye Institute, Utrecht University, Utrecht, The Netherlands ...