San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

Detroit Lions head coach Dan Campbell made a brutally honest admission about the team's loss to the San Francisco 49ers in ...

The Detroit Lions’ rebuild was jumpstarted by the fact that the first pick of the Brad Holmes and Dan Campbell, which was ...

The Detroit Lions visit the San Francisco 49ers on Monday at 8:15 p.m. ET, in a matchup featuring a pair of the best ...

If the Minnesota Vikings win, then this game will not have an impact on the Lions' ability to clinch. However, a Vikings loss ...

All three Saturday games on the Week 17 NFL schedule will have a significant impact on the NFL postseason. The Los Angeles ...

The news is much better for the Chargers, as their No. 1 back J.K. Dobbins is set to return today four weeks after suffering ...

For Lions defensive coordinator Aaron Glenn's money, 49ers star George Kittle is the best tight end in football.

SportsLine expert Eric Cohen reveals his score predictions for the 14 remaining games in Week 17 of the NFL schedule ...

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

The Lions will face a 49ers offensive line that could be starting two tackles signed off practice squads this week ...

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC Championship ...