Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting ...

The venture capital firm Flagship Pioneering has publicly launched the start-up Terrana Biosciences, which is using RNA to program plants to resist pests and disease. With a $50 million initial ...

RNA editing is positioned to be a breakthrough modality for multiple medicines. “We are incorporating proven components from other modalities for mechanism of action, administration ...

If DNA is too damaged, there will be mutations that are inherited,” said Rachel Green, an RNA biologist at Johns Hopkins University who co-authored the Cell study. “But amazingly, it’s the RNA that ...

For decades, the central dogma of molecular biology—DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease. This model ...

DNA polymerase was isolated in 1956; RNA polymerase, in 1959. Wave Life Sciences, a clinical- stage RNA medicines company, develops A-to-I RNA base editing oligonucleotides (“AIMers”). AIMers ...

What makes these discoveries revolutionary is what all this noncoding RNA—abbreviated as ncRNA—does. Much of it indeed seems involved in gene regulation: not simply turning them off or on but ...

About 1,000 microRNAs have been identified in people, and while knowledge about the field is still in its infancy, these small pieces of RNA appear to be involved in a multitude of important ...

The researchers tested the RNA origami in a lipid vesicle, a simple cell model system widely used in biology. Using so-called RNA aptamers, the artificial cytoskeleton was bound to the cell membranes.

RNA strands zip up into a double helix that blocks their replication. Like velcro, these are hard to pull apart and quick to stick back together, leaving no time to copy them.