Watch the best plays from Buffalo Bills running back James Cook during Week 4 of the 2025 NFL season against the New Orleans Saints.

Highlights from the Week 4 matchup between the New Orleans Saints and the Buffalo Bills during the 2025 NFL season.

It was tougher than expected but the Buffalo Bills defeated the New Orleans Saints, with these winners and losers standing out in Week 4.

Buffalo Bills quarterback Josh Allen spoke out and didn't hold back about his team after an ugly win over the Saints.

The New Orleans Saints dropped to 0-4 on the season after a 31-19 loss to the Buffalo Bills. Despite an early back-and-forth ...

The Bills (4-0) kept their winning ways going in Week 4 against the New Orleans Saints (0-4) in a 31-19 final. While a win, Buffalo kept a bit of a tradition going. The Bills allowed the Saints to ...

ORCHARD PARK, N.Y. (KPLC) - The New Orleans Saints travel to Highmark Stadium to take on the Buffalo Bills for Week 4 of the ...

The Bills and Saints play Sunday in Week 4 of the 2025 NFL season.

ORCHARD PARK, N.Y. (WVUE) - The New Orleans Saints made it interesting in the fourth quarter (trailing 21-19), but couldn’t ...

Josh Allen threw two touchdown passes and ran for a score, and the Buffalo Bills shook off a sloppy first three quarters to stay undefeated, beating the winless New Orleans Saints 31-19.

Week 4 in the NFL was kind to some quarterbacks, and brutal to others. As is the case each and every week, signal-callers are under the microscope. Unless your ...

The New Orleans Saints fall to 0-4 to open the 2025 season after suffering a defeat in Buffalo against the powerful Bills.The final score Sunday afternoon 31-19.The Black & Gold are now 0-4 to open a ...