McCaffrey is battling Achilles tendinitis that first cropped up in Week 17 last season. There was some hope he’d return for the season opener, but he missed that game before landing on the injured list where he’s been since Week 2 with no firm timetable for his return.

The San Francisco 49ers lost another running back on Thursday night, with fill-in starter Jordan Mason exiting Week 6's victory over the Seattle Seahawks with a shoulder injury. They'll have to make do,

The San Francisco 49ers have been doing pretty well running the ball without the injured Christian McCaffrey as Jordan Mason has stepped in well. But let’s face it: no one is like McCaffrey, who was the NFL’s offensive player of the year after a monster year of running and catching the football.