The New York Giants had scouts spread out over the country this past weekend, including at Penn State vs. Oregon.

The New Orleans Saints, led by quarterback Spencer Rattler, face the Buffalo Bills, led by quarterback Josh Allen on Sunday, Sept. 28, 2025 at Highmark Stadium in Orchard Park, N.Y.

The Buffalo Bills are heavily-favored as they host the New Orleans Saints in Week 4. Here's all you need to know to see them in action.

They'll have a friendlier matchup in Week 4 to get their third down defense in check. The Saints played in a similar hostile ...