Here, the authors show that resistance to these drugs is due to Hepatoma up-regulated protein (HURP) competitively binding to the same site on tubulin, countering the drug’s effects. This study ...

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New 1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-phenylisoquinoline-1(2H)-ones as Phosphoinositide 3-kinase Inhibitors for Treating Cancer and other Diseases.

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