An androgen synthesis inhibitor is a type of drug which inhibits the enzymatic synthesis of androgens, such as testosterone and dihydrotestosterone (DHT). [1] They include: Inhibitors of cholesterol ...

influences the secretion of collagen by cultured foreskin fibroblasts raised from patients with normal or undetectable DHT-binding activity (complete androgen resistance). Collagen synthesis and ...

3) A defect in androgen synthesis that results in increased ovarian androgen production. We will discuss each of these theories in more detail. Insulin resistance, defined as reduced glucose ...

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In this randomized controlled trial of pediatric patients with congenital adrenal hyperplasia (CAH), it was found that ...

Since 2014, overall survival (OS) has been prolonged with addition of other systemic therapies, such as adrenal androgen synthesis blockers, potent androgen receptor blockers, or docetaxel, to ADT.

Spironolactone is an aldosterone antagonist that works well to control hirsutism by interfering with androgen synthesis. The recommended dose of spironolactone is 100-200 mg/day in 2 divided doses.