KRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer cells. These oncogenic mutations promote ...
In this issue of The EMBO Journal, Pizzagalli and colleagues present proof-of-principle analyses of immune cell motility ...
AdipoR1 selectively recognizes adipokine ligands, differentially shaping T-cell immune outcomes. CTRP9 engages AdipoR1 to ...
Over the past decade, several tumor-based predictors of cetuximab efficacy have been identified, yet most function as ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The compositional perturbation autoencoder ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Tank-binding kinase 1 (TBK1) is a Ser/Thr ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ER-phagy, a selective form of autophagic ...
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The structure of auxin‐binding protein 1 (ABP1) from maize has been determined at 1.9 Å resolution, revealing its auxin‐binding site. The structure confirms that ABP1 belongs to the ancient and ...
Brassinosteroids (BRs) are important plant hormones involved in many aspects of development. Here, we show that BRASSINOSTEROID SIGNALING KINASEs (BSKs), key components of the BR pathway, are ...
The endoplasmic reticulum (ER) and mitochondria form contacts that support communication between these two organelles, including synthesis and transfer of lipids, and the exchange of calcium, which ...
Eukaryotic translation initiation factor (eIF)3 is the largest eIF (∼650 kDa), consisting of 10–13 different polypeptide subunits in mammalian cells. To understand the role of each subunit, we ...
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