The protein homeostasis (proteostasis) network (Balch et al, 2008), consisting of a collection of molecular chaperones, ...

The enteric nervous system (ENS), the largest division of autonomic nervous system, is a tantalizing frontier in neuroscience. With the advent of single-cell transcriptomics, the ENS has been ...

Inherited metabolic diseases are rare monogenic conditions that disrupt biochemical pathways, affecting energy production and ...

Image data are universal in life sciences research. Their proper handling is not. A significant proportion of image data in research papers show signs of mishandling that undermine their ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Faecal microbiota transplantation ameliorates ...

Lung adenocarcinoma (LUAD) continues to pose a significant mortality risk with a lack of dependable biomarkers for early noninvasive cancer detection. Here, we find that aberrant lipid metabolism is ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Specific and non-invasive diagnostic tools are ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Esophageal squamous cell carcinoma (ESCC) is ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The gastrointestinal epithelium constitutes a ...

LINE1 (L1) retrotransposons have gained notoriety for their involvement in a slew of pathologies. While improper de-repression of L1 transcription may drive disease, mammalian cells have coopted L1 ...

In this report, we describe a unique human UBL‐type modifier named u biquitin‐ f old m odifier 1 (Ufm1) that is synthesized in a precursor form consisting of 85 amino‐acid residues. We also identified ...

The repair of oxidative base lesions in DNA is a coordinated chain of reactions that includes removal of the damaged base, incision of the phosphodiester backbone at the abasic sugar residue, ...