Is it safe to take acetaminophen? Yes, it's usually safe when taken according to the directions on the label. But taking more than that can cause liver damage, liver failure, or even death.

Acetaminophen (APAP), although recognized as a safe and effective antipyretic and analgesic drug, can lead to acute liver failure if taken in excess.

This separates the liver into three zones with different tasks ... we wanted to test how well this drug worked to repair the ...

3. Taking too much acetaminophen at one time or too many doses close together can cause liver damage, Tsourounis says. So stick to 3,000 milligrams of the drug at most per day, and don’t mix it ...

In rare cases, some people might also experience liver or kidney damage from using acetaminophen. This typically occurs when the drug has been used excessively. On the other hand, some common side ...

Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; caplets. May potentiate anticoagulants, hypoglycemics, methotrexate. May antagonize uricosurics. Increased risk of liver toxicity and/or GI bleed ...

Increased risk of liver toxicity and/or GI bleed with ≥3 alcoholic drinks/day or concomitant other drugs containing acetaminophen, NSAIDs. Caution with diuretics, corticosteroids.