Eukaryotic translation initiation factors in trypanosomatids display a fascinating divergence from those in higher eukaryotes. Foundational research has revealed that these parasites possess multiple ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, No. 6 (Mar. 15, 1985), pp. 1648-1652 (5 pages) To study the mechanism of translation we have attempted to ...

Nuclear-encoded regulatory proteins control mitochondrial translation. A few, however, are encoded by the mitochondrial DNA (mtDNA) and are produced by the mitochondrial translation machinery.

This infographic shows a concise overview of the present study, which investigated the key underlying mechanism called RAN translation that has implications in the pathology of multiple ...

Three new studies provide structural clues about how ribosomes and RNA polymerase are coupled to one another during bacterial gene expression. Both teams found that when the mRNA spacer between RNA ...

The Merrick laboratory seeks to identify all of the eukaryotic translation initiation factors and determine their sequential utilization in the initiation pathway. A secondary goal is to characterize ...

Protein is the fundamental substance of life. The genetic code directing protein synthesis is stored in DNA. When a cell is instructed, the code information transfers from DNA to mRNA. Then, ...