Study shows how telomerase can run amok, deleteriously capping damaged DNA, were it not for a first responder to DNA damage. The natural ends of chromosomes appear alarmingly like broken DNA, much as ...

Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is ...

Telomerase may be a nearly universal anticancer drug target: Inhibitors of this human enzyme might be able to treat most cancers without significant side effects. Telomerase is an enzyme that ...

Telomerase synthesizes DNA sequences that protect the integrity of chromosome ends. A model for how the components of this enzyme complex co-assemble offers insight into its structure and function.

Neuroblastoma is a pediatric solid tumor of the sympathetic nervous system. 1 Clinical courses of patients with neuroblastoma vary greatly, ranging from spontaneous regression to fatal progression.

Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...

Our DNA is organized into chromosomes, and the ends of chromosomes are protected with caps called telomeres; when cells divide, they lose a very small amount of DNA from those ends. Short telomeres ...

Cancer, aging-related diseases and other illnesses are closely tied to an important enzyme called "telomerase." UCLA researchers report in the journal Cell the deepest scientific understanding yet of ...

Researchers at the Salk Institute have discovered an on/off switch for telomerase, an enzyme that rebuilds a cellular timekeeper known as a telomere. The scientists believe that the discovery could ...

Of the many components in the cell thought to play a role in cancer, few have received more attention in recent years than an enzyme that has been dubbed a cellular fountain of youth. Known as ...

Nothing in your body lasts forever. Every single cell in your body will die eventually, and eventually you’ll run out of replacements. When that happens, various parts of your body will stop working ...

Negative results and findings in science are perhaps less newsworthy, but they are no less important. Particularly when, as in this case, they demonstrate that a possible new therapeutic pathway ...