GLP‑1 medications such as Ozempic and Wegovy work by mimicking a hormone that signals fullness to the brain and gut. But once the injections stop, experts warn the body may begin producing less of that natural hormone and may also become less sensitive to it — increasing the likelihood of overeating.

Findings from a new meta-analysis suggest that if the drugs aren’t continued, other weight management interventions may be required to maintain benefits.

How long it takes to lose weight can vary based on a number of factors, such as age, medications you take, your activity level, and more. Learn how to do it right.

The sustainability of weight-loss drugs is under scrutiny as new research shows that people who stop taking glucagon-like peptide-1 (GLP-1) agonists regain the pounds at a steady rate, returning to their original size after around 1.

Will 2026 mark the end of crash dieting? Experts reveal the truth behind weight loss myths, metabolism damage and why slow change finally wins.

A major study finds that weight loss drugs work while used, but weight and health benefits often return after stopping treatment.

Regardless of how much weight was lost, monthly weight regain was faster after weight-loss drugs than after behavioral weight management programs, the researchers also found.

Stopping weight loss drugs is followed by weight regain and reversal of beneficial effects on heart and metabolic health markers such as high cholesterol and high blood pressure, finds a study published by The BMJ today.