This genetic model suggests otherwise, indicating that coupled gating or other mechanical interactions, rather than CICR, drive activation of uncoupled RyR1 channels. Interestingly, the researchers ...

As people age, muscles naturally lose mass and strength, a condition known as sarcopenia. The decline can make everyday activities harder and increases the risk of falls, disability and early death.

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Abnormally high blood sugar (glucose) levels can result in Type 2 diabetes when things go awry with the body's skeletal muscle, which plays a key role in regulating glucose. Scientists are using in ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...