One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key "zones" that perform specific major tasks. So, if scientists hope to create ...

When mice with liver injuries received organoid tissue transplants, more of those receiving the multizonal versions (MZ organoids) survived longer than mice receiving either zone 3-only or Zone 1-only ...

So, if scientists hope to create self-growing patches of liver organoid tissue that could help repair damaged organs, it's important that the lab-grown tissue faithfully reproduce such zones.

When these humanised organoids were transplanted into rodents whose own liver-bile duct system had been disconnected, the ...