A new study identifies recessive, loss-of-function mutations in IDH3B, encoding a subunit of the NAD-specific isocitrate dehydrogenase, in individuals with retinitis pigmentosa. The lack of any ...

Like most medical students, I struggled to memorize the Krebs cycle, the complex energy-producing process that takes place in the body's mitochondria. Rote learning of Sir Hans Krebs' eponymous ...

In an advance toward understanding the origin of life on Earth, scientists have shown that parts of the Krebs cycle can run in reverse, producing biomolecules that could jump-start life with only ...

Metabolism is a key process in living things that enables fuel to be turned into energy, but its evolutionary origin is a long-standing enigma. Now, a study by US researchers has found a simple ...

Two simple molecules can react to form most of the intermediates in an analog of the modern-day Krebs cycle, without the need for enzymes or metals, according to a new study (Nat. Chem. 2020, DOI: ...

A set of biochemical processes crucial to cellular life on Earth could have originated in chemical reactions taking place on the early Earth four billion years ago, believes a group of scientists. A ...

If you took biochemistry classes, chances are good you remember memorizing the Krebs cycle, a well-known metabolic pathway in which sugars are converted through a series of steps to generate ATP, a ...

IF WE want to understand the nature of life, we have to think about the flow of energy and matter. So argues biochemist and writer Nick Lane in his new book Transformer. Quoting the poem Like Most ...