Week 2 of the 2025 college football season begins Saturday with a handful of intriguing matchups in the early window, and the main event -- which happens to be the only ranked-on-ranked game of the entire weekend -- coming later in the day.

Clemson enters fresh off a College Football Playoff quarterfinal run and brings back the core of a team widely viewed as a national title contender. Junior quarterback Cade Klubnik leads the charge after a breakout 2024 season with 3,639 yards, 36 touchdowns and just six interceptions.