Using powerful new visualization technologies, researchers have captured the first 3-D images of the structure of a key muscle receptor, providing new insights on how muscles develop across the animal ...
The findings could have implications for robotics, prosthetics and energy efficient machines. John McGrath and José Alvarado with HillBot, a robot designed to test parameters of muscle strength and ...
A research group has uncovered important details about how platelet-activating factor (PAF)—a powerful molecule involved in inflammation and allergic reactions—triggers contractions in the smooth ...
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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...
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