Every cell in your body faces the same engineering puzzle: how to cram roughly two meters of DNA into a nucleus just a few ...

From memory formation to disease prevention, scientists are uncovering how chromatin structure, enzyme evolution, and epigenetic regulators orchestrate gene activity. Recent breakthroughs reveal how ...

DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" ...

DNA inside the nucleus is not packed as a rigid regular fiber-linker histone H1 dynamically binds and loosely "glues" ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

The upper right portion illustrates viral nucleosome-like particles formed by co-occurring viral histone triplets and singlets. On the lower right, a network depicts distinct types of viral ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

In the early 1980s, David Gilmour, now an emeritus biochemistry and molecular biology professor at Pennsylvania State University, joined the laboratory of geneticist and biochemist John Lis as a ...