Targeted protein degradation is an emerging technology that has the potential to treat cancer and other diseases in a novel way. Like traditional inhibiting drugs, protein degraders are small ...

Protein-degrader structure and function have been captured in unprecedented detail. Protein degraders are recognized as an exciting avenue for drug discovery and development, providing targeted ...

Researchers have identified the drivers of an extracellular protein degradation pathway, which could be the key to a new generation of therapeutics. In a recent study, chemists at Stanford University ...

Targeted protein degradation has opened up a new field of drug discovery with potential to treat previously 'undruggable' diseases. The work means new drugs can be much more accurately targeted at the ...

Targeted protein degradation is a therapeutic strategy that utilizes the cell’s natural machinery to eliminate disease-causing proteins. The field traces its origins to the development of thalidomide ...

A team of scientists has used a novel approach to identify protein degraders that target Pin1, a protein involved in pancreatic cancer development. In drug discovery, targeted protein degradation is a ...

Living cells resemble highly organized small towns - in addition to energy production, transportation systems, and construction, cells also require efficient waste disposal. Most proteins, which shape ...

Targeted protein degradation (TPD) therapy is a promising new class of targeted treatments. Based on a cell’s natural mechanism for eliminating diseased proteins, this therapy can combat hard-to-treat ...