Reporting in The Journal of Physical Chemistry Letters, scientists used techniques called wide- and small-angle neutron scattering diffraction and spectroscopy to look at lipids, or fats in the fungal ...

Azoles are fungistatic agents, which bind to the fungal cell membrane and induce permeability changes causing an increase in fungal cell membrane permeability, leading to fungal cell damage ...

Mechanisms of Action of the Antifungal Agents Combination Antifungal Drug Therapy in Selected Fungal Infections Expert Commentary Five-year View References Sidebar ...

In a paper published in Mycology, a Chinese team of scientists revealed a sophisticated chemical dialogue between a host ...

Blocks synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of cytochrome P-450 dependent enzyme lanosterol 14α-demethylase responsible for the conversion ...

Spinning at 2-3 million times per second, their rotors cause fungal cells to disintegrate by disrupting their metabolism. "There are only a few classes of antifungals in clinical use," Santos said.

Spinning at 2-3 million times per second, their rotors cause fungal cells to disintegrate by disrupting their metabolism. "There are only a few classes of antifungals in clinical use," Santos said.

But instead of binding to ergosterol in the fungal cell membrane as amphotericin B does, mandimycin binds to the phospholipids, creating holes in the membrane that lead to cell death.