Unlike bacterial cyclic dinucleotides, cGAMP produced by cGAS is formed by an unusual combination of one conventional 3′ to 5′ phosphodiester bond, similar to the bonds found in DNA and RNA ...

DNA is made up of adenine-thymine (AT) bonds and guanine-cytosine (GC) bonds. The frequency of each type of bond differs substantially across bacterial species. A new study uses this quirk of ...