Complement C5a is a known mediator of inflammatory and neuropathic pain. In a new study, patients with NMOSD who were in remission and healthy controls were asked to rate their pain on a visual analog ...

However, some complement components, such as complement 5a (C5a), act as strong mediators of inflammation. Because in some cases inflammation can promote cancer growth, John Lambris at the University ...

Researchers at the University of São Paulo (USP) in Brazil have identified a new class of molecules capable of stopping the excessive inflammation typical of the severe form of COVID-19 without ...

PHILADELPHIA -- An investigational monoclonal antibody targeting C5a complement, when partially or fully substituted for corticosteroids, appeared to help patients with ANCA-associated vasculitis (AAV ...