Both the Boston Celtics and Cleveland Cavaliers may be without multiple key players in Wednesday night's matchup.

For the past three outings, the franchise has been without its two-time All-Star point guard Darius Garland, who’s dealing with a toe injury that limited him during last year’s postseason. Unsurprisingly, Garland will extend his absence to four games when the Cavaliers face the Detroit Pistons on Monday night.

Jaylen Brown scored 30 points, including 13 during a 20-3 run to end the first half that helped the Boston Celtics pull away from Cleveland to win 125-105 on Wednesday night and snap the Cavaliers' three-game winning streak.

A mock trade has the Cleveland Cavaliers sending De’Andre Hunter to the Sacramento Kings for two players. It has been a solid start to the new NBA season for the Cleveland Cavaliers as they have won two of their first three games to begin the season.

Last season's Eastern Conference powerhouses face off at Madison Square Garden tonight in their NBA opener tonight at 7 p.m. ET. Here's how to watch for free.

Cleveland led the conference for 165 straight days and it was the only team to produce three 2025 All-Stars (Donovan Mitchell, Darius Garland and Evan Mobley). Mobley also won Kia Defensive Player of the Year, while Kenny Atkinson was named Coach of the Year.

Karl-Anthony Towns and OG Anunoby each had a double-double and the host New York Knicks pulled away in the 4th quarter to beat the Cleveland Cavaliers

The NBA season rolls along this evening, and basketball fans can get an inside track on the action with these Cavs-Pistons betting picks.

The Cleveland Cavaliers enter a defining season carrying an NBA-record $392 million payroll and the pressure to make a deep playoff run.

The Celtics opened the year with a 0-3 record for the first time since the 2013-14 season, and the early schedule remains challenging for the upcoming week. An early slide may bring suggestions of tanking into focus from fans amid Jayson Tatum’s absence and a roster overhaul that stripped the team of several core players for financial reasons.