Pegcetacoplan significantly reduces proteinuria in patients with recurrent C3 glomerulopathy, or primary immune-complex ...

Complement is an ancient defense mechanism that evolved into a large protein-interaction network in mammals that initiates and serves innate immune functions and links innate immunity with adaptive ...

In a phase three, double blind, placebo controlled trial, pegcetacoplan significantly reduced proteinuria compared with ...

An inhibitory activity for an erythrocyte intermediate bearing the properdin ($\overline{\text{P}}$)-stabilized amplification C3 convertase, $\overline{\text{P ...

PHILADELPHIA - A team from the University of Pennsylvania School of Medicine and Utrecht University has deciphered a key step in an evolutionarily old branch of the immune response. This system, ...

Reviews of Infectious Diseases, Vol. 5, Supplement 4. Bacterial Virulence and Pathogenicity (Sep. - Oct., 1983), pp. S797-S805 (9 pages) An experimental model of pneumococcal bacteremia in guinea pigs ...

The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...

Please provide your email address to receive an email when new articles are posted on . In a first-in-human phase 1/2 study, GT005, an AAV2-based one-time investigational gene therapy, showed ...

With Alzheimer’s disease therapies finally reaching the market and hundreds of active clinical trials for therapies and diagnostics, it seems like every week brings another potential avenue to explore ...

It was called ‘complement’ because it aided the antibacterial activity of antibodies. However, it is now known that the complement system can be activated early in an infection without the presence of ...