From the food you eat to the way your cells function, biomolecules are at the heart of it all. Carbohydrates, proteins, lipids, and nucleic acids each play unique roles in energy, structure, and ...

An image of biomolecules, such as nucleic acids, lipids and proteins, in live cells using an imaging technique called infrared (IR) transmission microscopy. To accelerate biotechnology innovations, ...

Lipids are a class of biomolecules that play an important role in many cellular processes. Analyses that seek to characterize all lipids in a sample—called lipidomics—are crucial to studying complex ...

TEMI mapping of lipid distribution across cerebellar layers. This image shows lipid species specifically enriched in three distinctive layers of the cerebellum: molecular layer, white matter layer and ...

If you were to use infrared (IR) transmission microscopy, you would appreciate its chemical quantification abilities—unless your object of study was a hydrated cell. In that case, you might complain ...

The cell membrane, the wall-like boundary between the cell interior and its outside environment, is primarily made up of two kinds of biomolecules: lipids and proteins. Different lipid species closely ...

Researchers have recently shed light on how cell membrane proteins could be influenced by the lipids around them. By developing a novel type of membrane model, they were able to show that the shape ...

Imaging live cells without disrupting their natural behavior or damaging their structures is one key challenge in biomedical optics, and has been tackled in multiple ways. A project at NIST has now ...

For biologists, seeing is believing. But sometimes biologists have a hard time seeing. One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of ...

Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) is a powerful analytical technique that enables spatially resolved molecular analysis of biological tissues. It ...