Scientists identify the protein DeltaFosB as the "master switch" that rewires the brain's memory and reward circuits, driving chronic cocaine addiction and relapse.

Cocaine addiction isn’t simply a failure of willpower — it’s the result of lasting biological changes in the brain.

The brain disease model promised clarity, but reality stayed messy For decades, the dominant scientific story has framed addiction as a chronic brain disease, a view popularized to counter the idea ...

A few weeks ago I participated in an hour-long talk show, via Skype. It's called The Agenda with Steve Paiken, and a lot of Canadians watch it. I was a bit nervous that night. Behind me the camera ...

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When a cocaine addict relapses, it isn't a matter of personal failure—it's the biological result of their brain's rewiring, ...

Addiction is one of the most common and consequential chronic medical conditions in the United States. Nationwide, more than 46 million people met the criteria for a substance abuse disorder as of ...

Preclinical studies in animals have already shown that GLP-1 drugs can reduce reward-seeking behavior. Early clinical work in humans has begun to hint at similar effects. A randomized trial of ...

"If addiction is a disease, is it fair to punish people for showing symptoms of it? That's the question raised by a case going before the Massachusetts Supreme Court next week, one that has national ...

Prescription weight loss drugs have been lauded as the miracle drug for treating diabetes and obesity, but new research suggests that these drugs, known as glucagon-like peptide-1 (GLP-1) ...

A new study found GLP-1 drugs were associated with 50% fewer substance-related deaths, 39% fewer drug overdoses, and 26% ...