St. Joseph is a city in and county seat of Buchanan County, Missouri, United States. A small portion of the city extends north into Andrew C…St. Joseph is a city in and county seat of Buchanan County, Missouri, United States. A small portion of the city extends north into Andrew County. Located on the Missouri River, it is the principal city of the St. Joseph Metropolitan Statistical Area, which includes Buchanan, Andrew, and DeKalb counties in Missouri and Doniphan County, Kansas. As of the 2020 census, St. Joseph had a total population of 72,473, making it the 8th most populous city in the state, and the 3rd most populous in Northwest Missouri. St. Joseph is located roughly thirty miles north of the Kansas City, Missouri, city limits and approximately 125 miles south of Omaha, Nebraska.
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